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The proposed logic of NNMT inhibition is straightforward on paper: block the methylation reaction, and nicotinamide is spared for NAD + resynthesis while SAM is spared for methylation reactions elsewhere
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Abstract Curcumin, a bioactive polyphenol derived from turmeric ( Curcuma longa ), has garnered substantial attention for its potent anti-inflammatory, antioxidant, and antineoplastic properties